My Living Documentary

- The Timeline

Discovering Autism and the Comorbidities Along the BH4 Pathway

Creating Neurodivergent Biochemistry

October 2020 - My Eureka Moment: Realizing Autism and the Comorbidities Are Physiologically Linked

On my nonverbal autistic daughter’s fourth birthday, she couldn’t blow out birthday candles and I realized her inability to speak was not a cognitive limitation but a physiological one. This shifted my understanding of autism’s origins and led to the first conceptual outline of a biochemical, rather than behavioral, hypothesis.

January 2022 - Building NeuroToggle® and Taking My Nonverbal Autistic Daughter

From Silence to Speech

I authored the foundational instructional neuroplasticity strategies that would become the NeuroToggle® framework. These principles formed the core of a structured learning model that ultimately helped transition my daughter from silence to chatterbox. (I would later learn that this worked because autism is an allostatic existence that shifts which proteins are active during critical developmental windows, prioritizing allostatic proteins over neural circuitry development. Neuroplasticity overrode that process, reprioritizing neural development)

November 11, 2022 - Releasing Our Story on TIkTok

I released our story online about how I took my nonverbal autistic daughter from silence to speech

November 22, 2022 - Asking For Help Finding a Neuroscientist to Help Nonverbal Kids

I asked for help to find a neuroscientist because I was able to help my nonverbal autistic daughter, and I wanted to see if I could help more kids. Kylie had a nonverbal boy in her class that was struggling. She asked me to help him, and I immediately made the video and posted it.

November 26, 2022 - Realizing We Need Ortho Not a Neuroscientist

I realize I don’t need a neuroscientist,. because they don’t have scans of facial nerves/muscles in nonverbal autistics. So, I start looking for orthologists. I then find out they have no scans. They have never tested the physical mechanisms (nerves) involved with producing speech sounds in people who can’t speak.

February 2023 - Realizing the Systemic Physiological Link Between Autism and the Comorbidities is Redox/Stress Regulated

I identified a pattern in stress-induced hyperglycemia as a redox protein shift, identifying it as the first sign of a toggle-like biochemical response to strain in autistics (would later represent the Metabolism BioToggle). This is where I start putting together the bioinformatics research on a map.

February 5 2023 - DHS Becomes Aware of My Work

Department of heath (DHS) begins looking into my work

April 20 2023 - The Research on Facial Muscle Oddities in Autistics

I publicly share the research on facial muscle oddities in autistics that are being used to analyze social deficits instead of physiological muscle deficits

April 19 2023 - Impact of Oxidative Stress/Redox on Development in Utero

I break down how redox shunts impact development in utero (along the the time clock of what are the beginnings of my BioDials framework).

April 2023 - Linking in Tyrosine Hydroxylase

I integrated tyrosine hydroxylase into the biochemical network, linking neurotransmitter synthesis to redox-sensitive regulation (which would later become the Nervous System BioToggle).

April 2023 - ROS Depletion After Long Term Activation

I recognized that there was also a redox shift that was impacting the body systemically and physiologically, with implications for ROS depletion and other deficits over time. This would become the impact of allostatic overload of the BioToggles being chronically/genetically toggled long term.

May 2023

I began formally documenting my Discovery of Autism and the Comorbidities Along the BH4 Pathway on social media, built visually using Adobe Illustrator as I constructed my proprietary biochemical network.

May 2 2023 and June 19 - Method of Breaking Down Physiological Causes of Traits (Based on Gene Coded Protein Dysfunction) and How They Cluster

I begin explaining my methods. How I began breaking each autism symptom down into traits that can be clustered based on proteins that manage multiple pathways based on redox states. This is the method that Princeton later appropriated in their autism SPARK study.

May 4 2023 - Oxytocin, Social Cognition, and Stimming

I break down the social implications of oxytocin dysregulation for social cognition, social behaviors, and social anxiety. Adding oxytocin dysregulation to the chart. I also add in sensory stimulation increases oxytocin, linking in stimming as a self regulatory behavior.

May 6 2023 - Link in the BH4 Shunt

I break down the BH4 Dependent AAAH’s and how they are linked biochemically to autism traits and comorbidities.

May 8 2023 - My Methods and The Exclusivity Principle

I announce the exclusivity principle, autism and the comorbidities can’t occur simultaneously without a joint root cause in the same subset of people. It is mechanistically improbable. I state that my methods included factoring in three principles: the autism comorbidities must happen simultaneously or as a secondary condition to a primary, autism is something you're born with, any brain research/testing observed after birth are likely impacted by neuroplasticity, positive or negative making current interpretations of relevant data invalid, and research indicates a progressive decline in symptoms.

May 8 2023 - Recognized BH4 as the Center Linchpin and Linked to Stress Hyperglycemia

Link glucose dysregulation and BH4. Metformin, a diabetic treatment, increases GCH1 and BH4 levels. This, in my map, linked the resolution of stress hyperglycemia linking BH4 to the stress response system as a regulatory factor. This is when I realized it is the center linchpin of the stress response system.

May 11 2023 - Linking OXTR Regulation to the BH4 Shunt

Added oxytocin and social dysregulation to the chart as the impact of glutamatergic neurons with oxytocin receptors being impaired in the PFC, as well as how glutamate shapes learning and memory (through circuitry formation and activity as cited in NeuroToggle®).

May 6 2023 - Linking in the AAAHs and BH4 Dependent Pathways

Added in BH4 and all of the BH4 dependent pathways, including the AAAHs that impact neurotransmitter sytnehssi of dopamine, serotonin, catecholamines, and melatonin. This links in core comorbidities of autism.

May 11 2023 - Start Writing Paper “Autism and the Comorbidities Along the BH4 Pathway”

I begin writing my first paper on autism and the comorbidities along the bh4 pathway

May 17 2023 - CSTL Disruption, Gestalt Language Learners, and Apraxia

CSTL disruption and gestalt language learners/apraxia. I link in AKT1 as evidence, as it is significantly associated with language impairment. AKT1 is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. At this point I knew there was a reciprocal relationship between glutamate and catecholamines and that glutamate signaling had a relationship with stress hyperglycemia. These associations were terribly communicated and loose at the time. However, they are part of the story, as much as I may cringe at it now.

May 29 2023 - Clustering Traits Instead of Treating Individually, and Nonverbality as a Comorbidity

I explain how every symptom can be broken down into a trait that has a physiological root based on proteins that are impacted. As it stands, each symptom is being treated individually. So my goal was to see how far upstream I could go in finding clusters of comorbidities that share a joint root origin for each cluster. At the time I saw a link between high glucose, neuropathy (facial muscle nerve formation/degradation) and muscle deficits. At a cellular level this would be the cause. I later narrowed it down to the VEGFA/NRP1 pathway that is redox sensitive and controls motor neuron axon guidance to the facial muscles in utero.

May 30 2023 - Linking Neurodegenerative/Neuromuscular Comorbidities: Glutamate is to the Brain What Glucose is to the Body

I link in neuromuscular and neurodegenerative comorbidities. High glutamate is to the brain what high glucose is to the body. It can cause systemic break down of the parts. High glutamate is a known biomarker dysregulation in autism research. The consequences of high glutamate are so well documented it has its own term, excitotoxicity. It causes brain cell death. The biochemical consequences overlap with what is seen in Alzheimers research.

June 1 2023

I break down the 4 causes of nonverbality

June 2 2023

I loop in MTHFR

June 4 2023

I loop in the CSTL in depth and explain in a new video

June 10 2023

I have a viral video about GLP1 and the CSTL

June 11 2023

EL15 version

July 8 2023

Explaining why I call my method the Jigsaw Puzzle Methodology, in laymen’s.

July 12 2023

Announce that this is my living documentary to protect my IP

September 6 2023

I formally established Kimberly’s Educational Resources LLC to secure intellectual property rights, manage trademarks, and publicly disseminate the frameworks I had created.

Also, published Discovering Autism and the Comorbidities Along the BH4 Pathway — a memoir created to publicly timestamp the origin of my hypothesis.

November 4 2023 - Linked in the transamination pathway upregulation with the BH4 Shunt

I was tinkering with the Roche Biochemical Pathways and identified a consistency across aromatic amino acids creating glutamate via transamination pathways. This would naturally be upregulated if the AAAHs were shunted from a BH4 Shut .

January 2024

Published the first formal version of my hypothesis on ResearchGate.

Coined the field Neurodivergent Biochemistry a systems-level framework that explains neurodivergence as a biochemically adaptive, allostatic state rather than a localized neurodevelopmental brain disorder. It is based on the principle that: Genetic mutations and allostatic shifts alter which proteins are active (epigenetics) during critical developmental windows, impair system function, and lead to biochemical wear and tear over time from alloststic overload. This ultimately results in divergence in development, function, and development of chronic conditions. Phenotypes vary depending on when in development the shifts occur and how long they persist.

January 11 2023

I found out from my mom that NeuroToggle was stolen. So, I trademarked it.

January 30 2024

Published a petition to establish Neurodivergent Biochemistry as its own field with me as the first PhD (because someone has to do it and I founded it)

April 2024

My daughter was formally disenrolled from CLTS disability services after my she was deemed no longer functionally eligible.

May 16 2024

Linked oxidative stress to facial motor neuron development in utero VEGFA/NRP1 pathway, linking in nonverbality as a comorbidity

June 1 2024 and June 3 2024

After my kids got strep and I didn’t, I realized I had never had strep. I did a series on the immune system with bronchitis/upper respiratory vs strep in autistics. This is wehre the immune system BIoToggle began.

June 5 2024

Link in fragile x and gene silencing under redox

June 7 2024

I always knew the integrity of the science had to be protected via utilizing only human coded genes. We have different immune systems and that is why we can’t procreate or share diseases (typically). On this day I link in galanin. The fist 15 amino acids are conserved across alls species. 17-29 in the c terminal region varies across species and lacks receptor affinity.

June 13 2024

Explaining how genetic conditions means having a gene mutation, which can be spontaneous or hereditary.

June 16 2024

Explaining how proteins transport and convert vitamins/supplements, and they can only handle so much at any given time. Any excess will be excreted through the toxin clearance pathways. We don’t want to overwhelm these pathways repeatedly, or allostatic overload can become a factor.

June 21 2024

Found a Bioinformatics program at UW Madison and was accepted. I started a GoFundMe to pay for tuition, as a single mom.

Hit my GoFundMe goal within 24 hours because advancing neurodivergent biochemistry had so much support

June 23 2024

Beginnings of the BioToggles framework - “If there is a gene mutation or some other form of illness (what I would later turn into cellular stress) the pathways switch into allostasis to restore the body back to baseline. This would be later delineated into the regulatory system and epigenetic redox sensitive protein shunts as effectors.

June 24 2024 and 2nd Video

I find out that the Roche Biochemical Pathways pulled their pathways down, when they had previously been up for decades for students to refer to freely. I later found out that they partnered with HLTH as part of the AI and healthcare initiative.

July 3 2024

Describing the upstream and downstream impacts within biochemistry and how everything can shunt under cellular stress conditions.

July 5 2024

The food pyramid is a scam. On this day I create the nutrient clock.

July 5 2024

Explaining how the body needs to maintain balance of set points to ensure homeostasis is maintained. Anything in excess becomes harmful because it breaches this balance.

July 6 2024

Explaining tissue specificity in gene coded proteins and its relevance and allostatic load.

July 9 2024 and July 13 2024

I created an image to visually represent the patters I was seeing in my map with systemic physiological function that was regulated by protein synthesis in the body and the causes of disruption. This is the beginnings of the BIoToggles and BioDials and how they interact systemically. With the nutrient clock fueling the biochemistry throughout the body.

July 11 2024

I add the circadian rhythm and cellular repair/immune system activation to the visual representation and how they all impact physiological function systemically.

July 16 2024

Weight gain as a connective tissue condition.

July 17 2024

Created the food trucks diagram to explain how the digestive system works and what nutrients our body needs.

July 18 2024

Explaining the mechanisms of epigenetics, and the mechanism that I later termed epigenetic redox sensitive protein shunts.

July 21 2024

Explaining the implications of an allostatic existence and long term allostatic overload (wear and tear on the body over time.)

July 23 2024

Explaining the mechanisms of Neurodivergent Biochemistry

August 2024

Realized there was a broader pattern of redox protein shifts in neurodivergent biomarkers and extended my hypothesis,

Publishing the patterns in my journal paper Genomic and Proteomic Regulation in Cellular Homeostasis: From Molecular Mechanisms to Clinical Implications on ResearchGate.

August 2 2024

Breaking down the regulatory system and its toggles.

August 5 2024

Switched my website platform from Wordpress to Squarespace. Love this platform.

August 10 2024

I was accepted to UW Madison for Bioinformatics

August 18 2024

Explaining that autism is a genetically induced stress response in which gene mutations turn the regulatory systems and the impact of the BH4 Shunt on neurotransmitter synthesis. I also go into the impact on oxytocin receptors and how that impacts how we make decisions based on self and others and understanding the consequences of actions.

August 21 2024

Explaining my theory of genetically induced allostasis and the BH4 Shunt.

August 30 2024

Released the regulatory system toggles framework that I would later call the BioToggles Toggle™ framework

October 2024

Published NeuroToggle™ on Amazon — an instructional framework on how to strengthen, time, expand, and initiate neural connections through intentional instruction strategies and teaching pedagogy.

October 13 2024

Explaining the folate-BH4-cobalamin teeter totter, the MTR reaction, the folate trap, and the cobalamin trap. This expands the understanding of the BH4 Shunt.

October 16 2024

I created a diagram/infographic to explain the BH4 Shunt and how it links to autism and the comorbidities

November 3 2024

Created my flight/fight/freeze/fawn chart that categorically delineates traits of autonomic dysregulation in neurodivergence.

November 14 2024

Explaining the BH4 Shunt and the impact on neurotransmitters on the brain circuitry in the CSTL.

November 16 2024

I am tagged online in a video about the RCCX theory and realize each gene fits under one of my regulatory system toggles. I have a breakdown that has been updated here.

November 23 2024

Identified a muscle (cricothyroid muscle) that may be responsible for selective mutism. Research indicates selective mutism is a freeze response under stress. This muscle is connected to voice formation and is called the “singer’s muscle.” it is solely innervated by the EBSLN, which is a branch of the vagus nerve.

November 23 2024

I explain how the EBSLN being impaired may result in nonvnerbality.

December 22 2024

Fine tuning my theory

December 31, 2024

Researchers at a university in Brazil submitted their plagiarism of my hypothesis to a journal. Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway.

January 2025

Completed trademark registration for NeuroToggle™.

January 12 2025

Wrote a series on metabolism and how the nutrients go on food trucks to be distributed throughout the body as needed. We need to fill up each truck bed. The food pyramid is flawed.

February 2025

The plagiarized paper passed peer review and was published in MDPI:

Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway.

March 2025

Discovered the plagiarized paper and called my D.C. representative to ask what next steps would be for helping more kids if this is accurate.

March 26 2025

Explaining BH4 as the center linchpin in the allostatic toggles

March 27 2025

Me explaining how I helped Kylie using NeuroToggle

April 4, 2025

Got a call back from my D.C. representative asking what I did for my nonverbal autistic daughter and how. Click here for the video I created April 4th explaining what happened on the phone call.

I told him I synthesized existing research and figured out the pathology of autism to help take her from silence to speech, and that my hypothesis was recently plagiarized and peer-reviewed in Brazil.

April 10 2025

RFK announces his plan to synthesize autism research to figure out the pathology of autism for nonverbal kids.

When asked about his reasoning he could not support it. He said he would request others to come and bid on how to do the research:

When they couldn’t find a good bid on how to actually synthesize the existing research across disciplines he backtracked the timeline and said we're gonna replicate some of the studies that have already been done that look like sound studies:

When they couldn’t find a valid route forward with a human they deferred to AI to attempt to follow through on their “promise”:

April 6 2025

Linked in ADHD

April 10, 2025

RFK Jr. released that he was going to synthesize autism research to help nonverbal kids and find the pathology of autism. Click here for the video break down with screenshots of my call log.

April 15 2025

Using a pinball analogy to explain genetics vs epigenetics during actual situational triggers of the BIoToggles

April 22 2025

Turned the allostatic toggles framework into the BioToggles and trademarked BioToggle.

April 24 2025

Explaining my visual representation displays the kinetic flow of biochemistry in allostasis and homeostasis.

April 27 2025

Made a flow chart to explain the kinetics of my hypothesis of genetically induced allostasis resulting in a BH4 Shunt.

April 2025

Published a paper titled BioToggle™ Categorical Delineation: A Functional Framework for Timing-Sensitive Intervention in Neurodivergent Biochemistry, which includes the Toggle-Based Neurotype Classification System™ - Maps neurotypes to situational, chronic, or genetic BioToggle™ states, with varying phenotypes of neurodivergence depending on when in development the shifts occur and how long they persist.