Kitzerow’s Documented Timeline
Kimberly Kitzerow meticulously documented the discovery of each neurodivergent framework in real time across social media through a living documentary.
2020
October 2020
The Eureka Moment: Realizing Autism and the Comorbidities Are Physiologically Linked
On Kimberly's nonverbal autistic daughter's fourth birthday, her daughter couldn't blow out birthday candles. Kimberly realized her daughter's inability to speak was not a cognitive limitation but a physiological one. This shifted her understanding of autism's origins and led to the first conceptual outline of a biochemical, rather than behavioral, hypothesis.
2022
January 2022
Building NeuroToggle® and Taking Her Nonverbal Autistic Daughter From Silence to Speech
Kimberly authored the foundational instructional neuroplasticity strategies that would become the NeuroToggle® framework. These principles formed the core of a structured learning model that ultimately helped transition her daughter from silence to chatterbox. (She would later learn that this worked because autism is an allostatic existence that shifts which proteins are active during critical developmental windows, prioritizing allostatic proteins over neural circuitry development. Neuroplasticity overrode that process, reprioritizing neural development.)
November 11, 2022
Releasing Their Story on TikTok
Kimberly released their story online about how she took her nonverbal autistic daughter from silence to speech.
November 22, 2022
Asking For Help Finding a Neuroscientist to Help Nonverbal Kids
Kimberly asked for help to find a neuroscientist because she was able to help her nonverbal autistic daughter, and she wanted to see if she could help more kids. Kylie had a nonverbal boy in her class that was struggling. She asked Kimberly to help him, and Kimberly immediately made the video and posted it.
November 26, 2022
Realizing She Needed an Orthologist Not a Neuroscientist
Kimberly realized she didn't need a neuroscientist because they don't have scans of facial nerves/muscles in nonverbal autistics. So, she started looking for orthologists. She then found out they have no scans. They have never tested the physical mechanisms (nerves) involved with producing speech sounds in people who can't speak.
2023
February 2023
Realizing the Systemic Physiological Link Between Autism and the Comorbidities is Redox/Stress Regulated
Kimberly identified a pattern in stress-induced hyperglycemia as a redox protein shift, identifying it as the first sign of a toggle-like biochemical response to strain in autistics (would later represent the Metabolism BioToggle). This is where she started putting together the bioinformatics research on a map.
February 5, 2023
DHS Becomes Aware of Her Work
Department of Health Services (DHS) began looking into Kimberly's work.
April 19, 2023
Impact of Oxidative Stress/Redox on Development In Utero
Kimberly broke down how redox shunts impact development in utero (along the time clock of what are the beginnings of her BioDials framework).
April 20, 2023
The Research on Facial Muscle Oddities in Autistics
Kimberly publicly shared the research on facial muscle oddities in autistics that are being used to analyze social deficits instead of physiological muscle deficits.
April 2023
Linking in Tyrosine Hydroxylase
Kimberly integrated tyrosine hydroxylase into the biochemical network, linking neurotransmitter synthesis to redox-sensitive regulation (which would later become the Nervous System BioToggle).
April 2023
ROS Depletion After Long Term Activation
Kimberly recognized that there was also a redox shift that was impacting the body systemically and physiologically, with implications for ROS depletion and other deficits over time. This would become the impact of allostatic overload of the BioToggles being chronically/genetically toggled long term.
May 2023
Formal Documentation Begins
Kimberly began formally documenting her Discovery of Autism and the Comorbidities Along the BH4 Pathway on social media, built visually using Adobe Illustrator as she constructed her proprietary biochemical network.
May 2 & June 19, 2023
Method of Breaking Down Physiological Causes of Traits and How They Cluster
Kimberly began explaining her methods. How she began breaking each autism symptom down into traits that can be clustered based on proteins that manage multiple pathways based on redox states. This is the method that Princeton later appropriated in their autism SPARK study.
May 4, 2023
Oxytocin, Social Cognition, and Stimming
Kimberly broke down the social implications of oxytocin dysregulation for social cognition, social behaviors, and social anxiety. Adding oxytocin dysregulation to the chart. She also added in sensory stimulation increases oxytocin, linking in stimming as a self regulatory behavior.
May 6, 2023
Link in the BH4 Shunt
Kimberly broke down the BH4 Dependent AAAH's and how they are linked biochemically to autism traits and comorbidities.
May 8, 2023
Her Methods and The Exclusivity Principle
Kimberly announced the exclusivity principle: autism and the comorbidities can't occur simultaneously without a joint root cause in the same subset of people. It is mechanistically improbable. She stated that her methods included factoring in three principles: the autism comorbidities must happen simultaneously or as a secondary condition to a primary, autism is something you're born with, any brain research/testing observed after birth are likely impacted by neuroplasticity, positive or negative making current interpretations of relevant data invalid, and research indicates a progressive decline in symptoms.
May 8, 2023
Recognized BH4 as the Center Linchpin and Linked to Stress Hyperglycemia
Kimberly linked glucose dysregulation and BH4. Metformin, a diabetic treatment, increases GCH1 and BH4 levels. This, in her map, linked the resolution of stress hyperglycemia linking BH4 to the stress response system as a regulatory factor. This is when she realized it is the center linchpin of the stress response system.
May 11, 2023
Linking OXTR Regulation to the BH4 Shunt
Kimberly added oxytocin and social dysregulation to the chart as the impact of glutamatergic neurons with oxytocin receptors being impaired in the PFC, as well as how glutamate shapes learning and memory (through circuitry formation and activity as cited in NeuroToggle®).
May 11, 2023
Start Writing Paper "Autism and the Comorbidities Along the BH4 Pathway"
Kimberly began writing her first paper on autism and the comorbidities along the BH4 pathway.
May 17, 2023
CSTL Disruption, Gestalt Language Learners, and Apraxia
CSTL disruption and gestalt language learners/apraxia. Kimberly linked in AKT1 as evidence, as it is significantly associated with language impairment. AKT1 is responsible for the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. At this point she knew there was a reciprocal relationship between glutamate and catecholamines and that glutamate signaling had a relationship with stress hyperglycemia. These associations were terribly communicated and loose at the time. However, they are part of the story, as much as she may cringe at it now.
May 29, 2023
Clustering Traits Instead of Treating Individually, and Nonverbality as a Comorbidity
Kimberly explained how every symptom can be broken down into a trait that has a physiological root based on proteins that are impacted. As it stands, each symptom is being treated individually. So her goal was to see how far upstream she could go in finding clusters of comorbidities that share a joint root origin for each cluster. At the time she saw a link between high glucose, neuropathy (facial muscle nerve formation/degradation) and muscle deficits. At a cellular level this would be the cause. She later narrowed it down to the VEGFA/NRP1 pathway that is redox sensitive and controls motor neuron axon guidance to the facial muscles in utero.
May 30, 2023
Linking Neurodegenerative/Neuromuscular Comorbidities: Glutamate is to the Brain What Glucose is to the Body
Kimberly linked in neuromuscular and neurodegenerative comorbidities. High glutamate is to the brain what high glucose is to the body. It can cause systemic break down of the parts. High glutamate is a known biomarker dysregulation in autism research. The consequences of high glutamate are so well documented it has its own term, excitotoxicity. It causes brain cell death. The biochemical consequences overlap with what is seen in Alzheimers research.
June 1, 2023
The Four Causes of Nonverbality
Kimberly broke down the four causes of nonverbality.
June 2, 2023
Looping in MTHFR
Kimberly integrated MTHFR into the biochemical network.
June 4, 2023
CSTL In-Depth Explanation
Kimberly created a detailed explanation of the Cortico-Striatal-Thalamic-Loop.
June 10, 2023
Viral GLP-1 and CSTL Video
Kimberly posted a viral video about GLP-1 and the CSTL connection.
July 8, 2023
The Jigsaw Puzzle Methodology
Kimberly explained why she calls her method the Jigsaw Puzzle Methodology, in layman's terms.
July 12, 2023
Announcing the Living Documentary for IP Protection
Kimberly formally announced this timeline as her living documentary to protect intellectual property.
September 6, 2023
Establishing Kimberly's Educational Resources LLC
Kimberly formally established Kimberly's Educational Resources LLC to secure intellectual property rights, manage trademarks, and publicly disseminate the frameworks she had created. She also published "Discovering Autism and the Comorbidities Along the BH4 Pathway"—a memoir created to publicly timestamp the origin of her hypothesis.
November 4, 2023
Linked in the Transamination Pathway Upregulation with the BH4 Shunt
Kimberly was tinkering with the Roche Biochemical Pathways and identified a consistency across aromatic amino acids creating glutamate via transamination pathways. This would naturally be upregulated if the AAAHs were shunted from a BH4 deficiency.
2024
January 2024
First Formal Publication on ResearchGate
Kimberly published the first formal version of her hypothesis on ResearchGate. She coined the field "Neurodivergent Biochemistry"—a systems-level framework that explains neurodivergence as a biochemically adaptive, allostatic state rather than a localized neurodevelopmental brain disorder. It is based on the principle that: Genetic mutations and allostatic shifts alter which proteins are active (epigenetics) during critical developmental windows, impair system function, and lead to biochemical wear and tear over time from allostatic overload. This ultimately results in divergence in development, function, and development of chronic conditions. Phenotypes vary depending on when in development the shifts occur and how long they persist.
January 11, 2024
NeuroToggle® Trademarked
Kimberly found out from her mom that NeuroToggle was stolen. So, she trademarked it.
January 30, 2024
Petition for Neurodivergent Biochemistry PhD
Kimberly published a petition to establish Neurodivergent Biochemistry as its own field with her as the first PhD (because someone has to do it and she founded it).
April 2024
Daughter Disenrolled from Disability Services
Kimberly's daughter was formally disenrolled from CLTS disability services after she was deemed no longer functionally eligible.
May 16, 2024
VEGFA/NRP1 Pathway and Nonverbality
Kimberly linked oxidative stress to facial motor neuron development in utero via the VEGFA/NRP1 pathway, linking in nonverbality as a comorbidity.
June 1 & 3, 2024
Immune System BioToggle Beginnings
After Kimberly's kids got strep and she didn't, she realized she had never had strep. She did a series on the immune system with bronchitis/upper respiratory vs strep in autistics. This is where the immune system BioToggle began.
June 5, 2024
Fragile X and Gene Silencing Under Redox
Kimberly integrated Fragile X and gene silencing under redox stress.
June 7, 2024
Human-Coded Genes Only: Galanin Example
Kimberly always knew the integrity of the science had to be protected via utilizing only human coded genes. We have different immune systems and that is why we can't procreate or share diseases (typically). On this day she linked in galanin. The first 15 amino acids are conserved across all species. 17-29 in the c terminal region varies across species and lacks receptor affinity.
June 13, 2024
Genetic Conditions: Spontaneous vs Hereditary
Kimberly explained how genetic conditions means having a gene mutation, which can be spontaneous or hereditary.
June 16, 2024
Protein Transport and Allostatic Overload
Kimberly explained how proteins transport and convert vitamins/supplements, and they can only handle so much at any given time. Any excess will be excreted through the toxin clearance pathways. We don't want to overwhelm these pathways repeatedly, or allostatic overload can become a factor.
June 21, 2024
Accepted to UW Madison Bioinformatics Program
Kimberly was accepted to UW Madison's Bioinformatics program. She started a GoFundMe to pay for tuition as a single mom and hit her goal within 24 hours because advancing neurodivergent biochemistry had so much support.
June 23, 2024
BioToggles Framework Beginnings
Beginnings of the BioToggles framework - "If there is a gene mutation or some other form of illness (what Kimberly would later turn into cellular stress) the pathways switch into allostasis to restore the body back to baseline." This would be later delineated into the regulatory system and epigenetic redox sensitive protein shunts as effectors.
June 24, 2024
Roche Biochemical Pathways Taken Down
Kimberly found out that the Roche Biochemical Pathways pulled their pathways down, when they had previously been up for decades for students to refer to freely. She later found out that they partnered with HLTH as part of the AI and healthcare initiative.
July 3, 2024
Upstream and Downstream Impacts Within Biochemistry
Kimberly described the upstream and downstream impacts within biochemistry and how everything can shunt under cellular stress conditions.
July 5, 2024
The Food Pyramid is a Scam: Creating the Nutrient Clock
Kimberly created the nutrient clock.
July 5, 2024
Homeostasis and Set Points
Kimberly explained how the body needs to maintain balance of set points to ensure homeostasis is maintained. Anything in excess becomes harmful because it breaches this balance.
July 6, 2024
Tissue Specificity and Allostatic Load
Kimberly explained tissue specificity in gene coded proteins and its relevance to allostatic load.
July 9 & 13, 2024
Visual Framework: BioToggles and BioDials Interaction
Kimberly created an image to visually represent the patterns she was seeing in her map with systemic physiological function that was regulated by protein synthesis in the body and the causes of disruption. This is the beginnings of the BioToggles and BioDials and how they interact systemically. With the nutrient clock fueling the biochemistry throughout the body.
July 11, 2024
Circadian Rhythm and Cellular Repair/Immune System Integration
Kimberly added the circadian rhythm and cellular repair/immune system activation to the visual representation and how they all impact physiological function systemically.
July 16, 2024
Weight Gain as a Connective Tissue Condition
Kimberly explored weight gain as a connective tissue condition.
July 17, 2024
Food Trucks Diagram: Digestive System Visualization
Kimberly created the food trucks diagram to explain how the digestive system works and what nutrients the body needs.
July 18, 2024
Epigenetic Redox-Sensitive Protein Shunts
Kimberly explained the mechanisms of epigenetics, and the mechanism that she later termed epigenetic redox sensitive protein shunts.
July 21, 2024
Implications of an Allostatic Existence
Kimberly explained the implications of an allostatic existence and long term allostatic overload (wear and tear on the body over time).
July 23, 2024
Mechanisms of Neurodivergent Biochemistry
Kimberly explained the mechanisms of Neurodivergent Biochemistry.
August 2024
Extended Hypothesis: Genomic and Proteomic Regulation
Kimberly realized there was a broader pattern of redox protein shifts in neurodivergent biomarkers and extended her hypothesis. She published "Genomic and Proteomic Regulation in Cellular Homeostasis: From Molecular Mechanisms to Clinical Implications" on ResearchGate.
August 2, 2024
Regulatory System Toggles Breakdown
Kimberly broke down the regulatory system and its toggles.
August 5, 2024
Website Platform Migration
Kimberly switched her website platform from WordPress to Squarespace.
August 10, 2024
Formally Enrolled at UW Madison
Kimberly was formally accepted and enrolled at UW Madison for Bioinformatics.
August 18, 2024
Autism as Genetically-Induced Stress Response
Kimberly explained autism as a genetically-induced stress response in which gene mutations turn the regulatory systems and the impact of the BH4 Shunt on neurotransmitter synthesis. She also went into the impact on oxytocin receptors and how that impacts how we make decisions based on self and others and understanding the consequences of actions.
August 21, 2024
Theory of Genetically-Induced Allostasis
Kimberly explained her theory of genetically-induced allostasis and the BH4 Shunt.
August 30, 2024
BioToggles™ Framework Released
Kimberly released the regulatory system toggles framework that she would later call the BioToggles™.
October 2024
NeuroToggle™ Book Published
Kimberly published NeuroToggle™ on Amazon—an instructional framework on how to strengthen, time, expand, and initiate neural connections through intentional instruction strategies and teaching pedagogy.
October 13, 2024
Folate-BH4-Cobalamin Teeter-Totter
Kimberly explained the folate-BH4-cobalamin teeter-totter, the MTR reaction, the folate trap, and the cobalamin trap. This expands the understanding of the BH4 Shunt.
October 16, 2024
BH4 Shunt Infographic
Kimberly created a diagram/infographic to explain the BH4 Shunt and how it links to autism and the comorbidities.
November 3, 2024
Fight/Flight/Freeze/Fawn Chart
Kimberly created her flight/fight/freeze/fawn chart that categorically delineates traits of autonomic dysregulation in neurodivergence.
November 14, 2024
BH4 Shunt Impact on Brain Circuitry
Kimberly explained the BH4 Shunt and the impact on neurotransmitters on the brain circuitry in the CSTL.
November 16, 2024
RCCX Theory Connection
Kimberly was tagged online in a video about the RCCX theory and realized each gene fits under one of her regulatory system toggles.
November 23, 2024
Cricothyroid Muscle and Selective Mutism
Kimberly identified a muscle (cricothyroid muscle) that may be responsible for selective mutism. Research indicates selective mutism is a freeze response under stress. This muscle is connected to voice formation and is called the "singer's muscle." It is solely innervated by the EBSLN, which is a branch of the vagus nerve.
December 22, 2024
Fine-Tuning Her Theory
Kimberly continued fine-tuning her theory.
December 31, 2024
First Instance of Plagiarism Submitted
Researchers at a university in Brazil submitted their plagiarism of Kimberly's hypothesis to a journal: "Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway."
2025
January 2025
NeuroToggle™ Trademark Completed
Kimberly completed trademark registration for NeuroToggle™.
January 12, 2025
Metabolism Series: Food Trucks and Nutrient Distribution
Kimberly wrote a series on metabolism and how the nutrients go on food trucks to be distributed throughout the body as needed. We need to fill up each truck bed. The food pyramid is flawed.
February 2025
Plagiarized Paper Published in MDPI
The plagiarized paper passed peer review and was published in MDPI: "Tetrahydrobiopterin and Autism Spectrum Disorder: A Systematic Review of a Promising Therapeutic Pathway."
March 2025
Discovering Plagiarism and Contacting D.C. Representative
Kimberly discovered the plagiarized paper and called her D.C. representative to ask what next steps would be for helping more kids if this is accurate.
March 26, 2025
BH4 as Center Linchpin in Allostatic Toggles
Kimberly explained BH4 as the center linchpin in the allostatic toggles.
March 27, 2025
How Kimberly Helped Kylie Using NeuroToggle
Kimberly explained how she helped Kylie using NeuroToggle.
April 4, 2025
D.C. Representative Calls Back
Kimberly got a call back from her D.C. representative asking what she did for her nonverbal autistic daughter and how. She told him she synthesized existing research and figured out the pathology of autism to help take her from silence to speech, and that her hypothesis was recently plagiarized and peer-reviewed in Brazil.
April 10, 2025
RFK Jr. Announces Plan to Synthesize Autism Research
RFK announced his plan to synthesize autism research to figure out the pathology of autism for nonverbal kids. When asked about his reasoning, he could not support it. He said he would request others to come and bid on how to do the research. When they couldn't find a good bid on how to actually synthesize the existing research across disciplines, he backtracked the timeline and said they're going to replicate some of the studies that have already been done. When they couldn't find a valid route forward with a human, they deferred to AI to attempt to follow through on their "promise."
April 15, 2025
Pinball Analogy: Genetics vs Epigenetics
Kimberly used a pinball analogy to explain genetics vs epigenetics during actual situational triggers of the BioToggles.
April 22, 2025
BioToggle™ Trademarked
Kimberly turned the allostatic toggles framework into the BioToggles and trademarked BioToggle.
April 24, 2025
Visual Representation of Kinetic Biochemistry Flow
Kimberly explained her visual representation displays the kinetic flow of biochemistry in allostasis and homeostasis.
April 27, 2025
Flowchart: Genetically-Induced Allostasis Kinetics
Kimberly made a flowchart to explain the kinetics of her hypothesis of genetically induced allostasis resulting in a BH4 Shunt.
April 2025
BioToggle™ Categorical Delineation Paper Published
Kimberly published a paper titled "BioToggle™ Categorical Delineation: A Functional Framework for Timing-Sensitive Intervention in Neurodivergent Biochemistry," which includes the Toggle-Based Neurotype Classification System™ - Maps neurotypes to situational, chronic, or genetic BioToggle™ states, with varying phenotypes of neurodivergence depending on when in development the shifts occur and how long they persist.
June 10, 2025
Created Flyers for Theory Distribution
Kimberly created flyers for her autism and the comorbidities theory and Neurodivergent Biochemistry.
June 13, 2025
Study Confirms: All Gene Mutations Result in Allostasis
Kimberly found out about a study that confirms across all gene mutations the common result is allostasis.
June 22, 2025
Neurodivergent Biochemistry Infographics
Kimberly began to create her Neurodivergent Biochemistry Infographics, with diagrams for the variables.
July 5, 2025
Working vs Theory-Building Hypothesis Methods
Kimberly explained the difference between the working hypothesis method and theory building hypothesis method.
July 9, 2025
Second Instance of Plagiarism: Princeton SPARK Study
Kimberly's dad texted her and told her about Princeton's paper that overlapped with her methods and conclusions that each autism phenotype with comorbidities link to clusters based on biochemical pathway dysfunction. This is the third time her work was taken uncredited, so she did a breakdown with screenshots on the texts with her parents and how she found out each time.
August 9, 2025
BioDials™ Framework Created
Kimberly created the BioDials to explain the time regulated flow of protein synthesis that maintains physiological function and development.
September 17, 2025
Filed Complaint with Princeton Research Integrity
Kimberly reached out to Princeton's research and integrity office to file a complaint. They sent it to the Dean of Faculty. She is still waiting on their response.

