Accessibility Long Description: Neurodivergent Biochemistry

This image presents a conceptual flow chart illustrating the Neurodivergent Biochemistry framework. It depicts how activation of the BioToggle regulatory systems affects human physiological function depending on whether the activation is situational, chronic, or genetically locked.

At the top of the diagram are five core physiological regulatory domains represented as BioToggles: the immune system, metabolism, cellular repair, the nervous system, and genetic regulation. Each BioToggle reflects a coordinated biochemical system that reallocates resources in response to stress, environmental demands, or genetic constraints.

Beneath these domains, the image shows three BioToggle activation states. In the first state, BioToggles are situationally “flipped,” indicating temporary activation in response to acute stressors, infection, or environmental load, with the expectation of returning to baseline. In the second state, BioToggles are chronically “stuck,” representing sustained activation over time that alters normal physiological regulation and adaptive capacity. In the third state, BioToggles are genetically “locked,” indicating heritable or epigenetically fixed patterns of regulatory activation that constrain physiological flexibility.

Arrows from these activation states converge downward into the BioDials system. The BioDials represent protein synthesis timing rhythms that regulate development, repair, metabolism, and neural function across circadian, developmental, and life-stage time scales. When BioToggles remain activated beyond adaptive limits, BioDial timing becomes dysregulated, affecting how and when proteins are produced and deployed across tissues.

At the bottom of the diagram, this dysregulation is shown to contribute to allostatic overload, where sustained regulatory activation exceeds the body’s capacity to maintain equilibrium. The image contrasts regulated development and function with allostatic overload outcomes, visually representing the transition from adaptive stress responses to systemic physiological strain.

Overall, the flow chart communicates that neurodivergent biochemistry arises not from isolated systems, but from integrated regulatory shifts across BioToggles, altered protein synthesis timing via BioDials, and cumulative allostatic load impacting whole-body function.