The 5 Core Frameworks
How the 5 Core Frameworks Integrate
Neurodivergent Biochemistry explains how stress alters development and function across connected biological systems over time, BioToggles categorize the type of stress activation occurring across regulatory systems, BioDials define the biological timing cycles disrupted by those shifts, NeuroToggle provides the instructional framework used to support neurodevelopment through neuroplasticity-based learning strategies, and the Autism and the Comorbidities Theory defines the resulting developmental, functional, and systemic outcomes that emerge across time.
Neurodivergent Biochemistry
Explains how stress alters development and function across connected biological systems over time.
Click to learn more → Framework 2BioToggles
Categorize the type of stress activation occurring across regulatory systems.
Click to learn more → Framework 3BioDials
Define the biological timing cycles disrupted by stress and regulatory shifts.
Click to learn more → Framework 4NeuroToggle
Supports neurodevelopment through structured neuroplasticity-based instructional strategies.
Click to learn more → Framework 5Autism and the Comorbidities Theory
Defines the resulting developmental, functional, and systemic outcomes that emerge over time.
Click to learn more →Kimberly Kitzerow
Educator specializing in data synthesis
- Helped her nonverbal autistic daughter speak using NeuroToggle.
- Organizes existing research into clear frameworks that explain neurodivergence, development, and comorbid traits.
Synthesizes data into frameworks by:
Analyzing existing raw data and research
Identifying patterns across findings
Organizing those patterns into systems
Presenting them in clear, usable structures
The Jigsaw Puzzle Methodology
How the theoretical model was built from existing biological data
The Jigsaw Puzzle Methodology explains how existing findings were organized into a coherent causal model rather than treated as isolated pieces of information.
Neurodivergent Biochemistry
Neurodivergent Biochemistry is the overarching framework that integrates five core frameworks, each explaining how stress shapes development and function based on the type of stress, when it occurs, and how long it lasts.
BioDials
The body’s timing systems
BioDials define the biological timing of function and development.
BioToggles
The stress-response systems
BioToggles categorize regulatory system stress categories.
Duration
How long stress lasts
The longer stress lasts, the more it can shape development and function.
NeuroToggle
The educational framework used to support development
Neural connections store how to perform skills and behaviors.
When those connections are disrupted, skill and behavior development is affected.
NeuroToggle uses neuroplasticity-based instructional strategies grounded in established teaching pedagogy to improve neural connectivity through instruction designed to:
Autism and the Comorbidities Theory
The outcomes of the model
Autism is a lifelong category aligned with the genetic domain, while neurodivergent traits and comorbidities are shaped across the remaining categories.
The Breakthrough and Validation
What began as Kimberly Kitzerow's effort to help her daughter speak led to the development of NeuroToggle® and the broader frameworks that followed.
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2020 - The Problem
Kimberly’s daughter was nonverbal and unable to coordinate the motor patterns required for speech.
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2020 - The Shift
When she could not blow out the candles on her fourth birthday cake, it revealed that the neural circuits required for coordinated speech were not functioning as intended.
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2021 - Building NeuroToggle®
Neuroplasticity was applied to build, strengthen, time, and expand those circuits into communication. This is the foundation of NeuroToggle®.
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2022 - The Results
Her daughter became conversational, and she began sharing their story online in the hopes of helping more children.
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2023 – Theoretical Model
Developed the Autism and Comorbidities Model, formed Kimberly’s Educational Resources LLC, and began writing.
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2024 – Framework Expansion
Developed Neurodivergent Biochemistry and documented the work through resources, websites, videos, and ResearchGate articles.
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2024 – Education + Funding
Crowdfunded for Bioinformatics at UW–Madison, earned all A’s, requested support, and was told a PhD was required before assistance.
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2025–2026 – Validation
Within months, independent research aligned with and validated the core pillars of this model at the mechanistic level.