The 5 Core Frameworks
The 5 Core Frameworks
This work is organized into five core frameworks. Each one explains a different layer of the system, from biochemical regulation to developmental timing, neurodevelopment, and learning.
Start with the framework most relevant to your question, or review the primary source list to distinguish the original mechanisms from the educational frameworks built from them.
Kitzerow’s Autism and the Comorbidities Theory
A systems-level theory proposing that autism traits and comorbid conditions are biochemically linked through shared pathway regulation under allostatic stress.
Neurodivergent Biochemistry
A molecular systems biology framework explaining how prolonged allostatic activation shifts biological priorities and disrupts typical development and function over time.
BioToggle
A regulatory systems framework defining the five biological domains that monitor, shift, and reprioritize function under stress: immune, metabolic, cellular repair, nervous system, and genetic regulation.
BioDials
A temporal systems framework describing how biological timing is coordinated across ultradian, circadian, circannual, developmental, and aging time scales.
NeuroToggle
A neuroplasticity-based educational framework focused on building, strengthening, timing, and expanding neural circuits to support learning, behavior, and adaptive development.
Primary Source Mechanisms
For researchers and readers who want to distinguish the original mechanistic sources from the educational and explanatory frameworks built from them, the primary source list organizes the foundational materials in one place.
How the 5 Core Frameworks Integrate
These frameworks operate as one integrated system. Together, they explain how stress activation alters development and function over time, how those shifts are categorized, how biological timing is disrupted, how neurodevelopment can be guided in response, and how long term outcomes emerge.
Neurodivergent Biochemistry explains how stress alters development and function over time.
BioToggles categorize stress activation, while BioDials define disrupted biological timing.
NeuroToggle guides neurodevelopment regardless of state.
Autism and the Comorbidities Theory defines the resulting outcomes.
1. Neurodivergent Biochemistry
Explains how stress alters development and function over time.
2. BioToggles
Define the category of stress activation across regulatory systems.
3. BioDials
Define the biological timing cycles disrupted by stress.
4. NeuroToggle
Guides neurodevelopment through structured learning strategies.
5. Autism and the Comorbidities Theory
Defines the long term developmental and functional outcomes.
In short, Neurodivergent Biochemistry explains system level change, BioToggles categorize stress, BioDials define disrupted timing, NeuroToggle guides development, and the Autism and the Comorbidities Theory defines outcomes.