Accessibility long description for this image: Kitzerow’s Autism and the Comorbidities Theory

The image is titled “Kitzerow’s Autism and the Comorbidities Theory.”

The diagram is structured as a bottom-up explanatory flowchart, with arrows indicating upward progression.

At the bottom of the image is a row of three labeled states:

“Situationally Flipped,”
“Chronically Stuck,”
“Genetically Locked.”

Above these states is a row of five regulatory system panels enclosed within a bracketed section. From left to right, the panels are labeled:

“Genetic Regulation,”
“Cellular Repair,”
“Immune System,”
“Metabolism,”
“Nervous System.”

Arrows point upward from these regulatory systems to a central horizontal section labeled “The BH4 Shunt.”

Adjacent to the BH4 Shunt are two labeled boxes.

To the left of the BH4 Shunt is a box reading:
“Stress Response Prioritized Over Typical BioDial Time Regulated Protein Synthesis That Manages Typical Development and Typical Function.”

To the right of the BH4 Shunt is a box reading:
“Stress Response Activation and Increased Neopterin.”

Above the BH4 Shunt is a row of three rectangular panels.

The left panel reads:
“NOS – Creates Nitric Oxide or When Uncoupled, Creates ROS and Peroxynitrite.”

The center panel reads:
“AAAHs – Create Dopamine, Serotonin, Melatonin, Norepinephrine and Epinephrine.”

The right panel reads:
“AGMO – Only Enzyme That Can Cleave Ether Lipids.”

Arrows point upward from these panels to another row of three panels.

The left panel reads:
“ROS-Induced Epigenetic Redox-Sensitive Protein Shunts as Regulatory System Effectors.”

The center panel reads:
“Upregulated Translational Pathways Increase Glutamate, Dysregulating E/I Balance in the CSTL.”

The right panel reads:
“Impacts Plasmalogens, Platelet-Activating Factor, Alkylglycerols, and Noladin Ether (Endocannabinoid System).”

Arrows continue upward to three labeled outcome categories near the top of the diagram:

“Comorbidities,”
“Autism,”
“Stress-Adaptive Signaling.”

Below each of these labels is a text box.

The box under “Comorbidities” reads:
“Autism and Comorbid Traits Cluster Predictably Based on Context Dependent Regulatory System Impact on Biochemical Pathway Activity.”

The box under “Autism” reads:
“Upregulated Translational Pathways Increase Glutamate, Dysregulating E/I Balance in the CSTL.”

The box under “Stress-Adaptive Signaling” reads:
“Created a Neuroplasticity Framework ‘NeuroToggle’ to reprioritize development and function of these pathways during critical time periods.”

Bidirectional arrows appear between these top-level categories, indicating interaction among comorbidities, autism traits, and stress-adaptive signaling.

A logo reading “Kimberly’s Educational Resources” appears in the lower right corner of the image.